EP 184: Rethinking speed and scale in clinical genomics with Euan Ashley of Stanford University

This week on The Genetics Podcast, Patrick is joined by Dr. Euan Ashley, Chair of the Department of Medicine at Stanford, founder of various biotech companies, and author of The Genome Odyssey: Medical Mysteries and the Incredible Quest to Solve Them. They discuss Euan’s groundbreaking work on ultra-rapid genome sequencing and how widespread sequencing, wearables, and AI could shape the future of preventive medicine and human performance.Show Notes: 00:00 Intro to The Genetics Podcast01:00 Welcome to Euan01:50 A pivotal case in Euan’s career involving diagnosing a newborn experiencing cardiac arrest06:41 How Euan’s team worked towards a record of eight hours from clinical sample to diagnosis10:05 Hurdles that need to be overcome before ultra-rapid sequencing workflows can be widely used in clinical settings11:40 Considerations around widespread genetic screening in newborns16:10 Weighing utility and uncertainty in genetic testing for disease19:17 Steps to a future where widespread genetic testing is economically viable 23:54 New frontiers of clinical genomics, including integration with electronic health records (EHRs) and wearables  28:24 The physiology and genetics of athletic performance and the inspiration behind the ELITE study33:54 Psychological drivers and effects of human performance37:57 Euan’s interest in generative AI for developing novel therapies41:32 Closing remarks Find out moreThe Ashley Lab (https://ashleylab.stanford.edu/)Please consider rating and reviewing us on your chosen podcast listening platform! https://drive.google.com/file/d/1Bp2_wVNSzntTs_zuoizU8bX1dvao4jfj/view?usp=share_link